Prevention starts at home: contributions from neuroscience

Authors

  • Maria Paula Magalhães Tavares de Oliveira Universidade de São Paulo (USP)

Keywords:

addiction, prevention, development, archetype, epigenetic

Abstract

The increase of drug abuse and of other behaviors that can lead to addiction are evident in contemporary world, as well as the difficulties related to addiction treatment. Neuroscience data can contribute to the prevention of this pathology. The present paper shows the importance of the decision-making process in addiction, focusing in the adolescent brain and emphasizing the role of intersubjectivity in the development. Recent studies describing epigenetic alterations related to early life adversities are presented, including data revealing that some alterations can be reverted by the quality of the bond with the caregiver. Prevention is discussed as an action that begins at home with the humanization of the great mother and the father archetypes and continues throughout life, once adversities can contribute to generate symptoms or resilience, depending on the stress intensity, the maturity level of the nervous system and the relationship between the child and the caregiver, being them parents, educators, friends, analysts or whoever the child can establish a significant relationship with.

Author Biography

Maria Paula Magalhães Tavares de Oliveira, Universidade de São Paulo (USP)

Doutora em psicologia experimental pelo Instituto de Psicologia da USP; analista membro da Sociedade Brasileira de Psicologia Analítica; colaboradora do Projeto Quixote.

References

BAUMAN, Z. O mal-estar da pós-modernidade. Rio de Janeiro: Zahar, 1998.

BOCK, J.; RETHER, K.; GRÖGER, N.; XIE, L.; BRAUN, K. Perinatal programming of emotional brain circuits: an integrative view from systems to molecules. Frontiers in neuroscience, v. 8. p. 1-11, 2014. Disponível em: https://doi.org/10.3389/fnins.2014.00011. Acesso em: 17 mai. 2015.

CAO-LEI, L.; MASSART, R.; SUDERMAN, M. J. et al. DNA methylation signature triggered by prenatal maternal stress exposure to a natural disaster: Project Ice Storm. Plos One, v. 9, n. 9, 2014. Disponível em: https://doi.org/10.1371/journal.pone.0107653. Acesso em: 17 mai. 2015.

CASEY, B. J.; JONES, R. M.; SOMERVILLE, L. H. Braking and accelerating of the adolescent brain. Journal of Research on Adolescence, v. 1, n. 21, p. 21-33, 2011. Disponível em: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3070306/. Acesso em: 5 mai. 2015.

CASEY, B. J.; CAIDLE, K. The teenage brain: self control. Current directions in psychological science, v. 22, n. 2, p. 82-87, 2013. Disponível em: http://journals.sagepub.com/doi/abs/10.1177/0963721413480170. Acesso em: 5 mai. 2015.

CONTI, G.; HANSMAN, C.; HECKMAN, J. J.; NOVAK, M. F. X.; RUGGIERO, A.; SUOMI, S. J. Primate evidence on the late health effects of early-life adversity. PNAS, v. 109, n. 23, p. 8866-8871, 2012. Disponível em: http://www.pnas.org/content/109/23/8866. Acesso em: 17 mai. 2015.

DAMÁSIO, A. Em busca de Espinosa: prazer e dor na ciência dos sentimentos. São Paulo: Companhia das Letras, 2003.

DETTMER, A.; SUOMI, S. J. Nonhuman primate models of neuropsychiatric disorders: influences of early rearing, genetics, and epigenetics. ILAR Journal, v. 55, n. 2, p. 361-370, 2014. Disponível em: https://academic.oup.com/ilarjournal/article/55/2/361/645985/Nonhuman-Primate-Models-of-Neuropsychiatric. Acesso em: 10 mai. 2015.

EIGSTI, I.-M.; ZAYAS, V.; MISCHEL, W. et al. Predicting cognitive control from preschool to late adolescence and young adulthood. Psychological Science, Washington DC, v. 17, n. 6, p. 478-484, 2006.

GALIAS, I. Pais e filhos: uma rua de mão dupla. Junguiana, São Paulo, n. 21, p. 69-80, 2003.

JUNG, C. G. Símbolos da transformação. Tradução Eva Stern. Petrópolis, RJ: Vozes, 1989. (Obras completas de C. G. Jung, v.5).

LUPIEN, S. J.; MCEWEN, B. S.; GUNNAR, M. R.; HEIM, C. Effects of stress throughout the lifespan on the brain, behavior and cognition. Nature Reviews Neuroscience, v. 10, n. 6, p. 434-45, 2009. Disponível em: http://www.nature.com/nrn/journal/v10/n6/abs/nrn2639.html. Acesso em: 02 dez. 2015.

MEANEY, M. J.; SZYF, M. Environmental programming of stress response through DNA methylation: life at the interface between a dynamic environment and a fixed genome. Dialogues in Clinical Neuroscience, Paris, n. 7, p.103-123, 2005.

MISCHEL, W., SHODA, Y.; RODRIGUEZ, M. I. Delay of gratification in children. Science, Washington DC, v. 244, n. 4907, p. 933-338, 1989.

MONK, C.; SPICER, J.; CHAMPAGNE, F. A. Linking prenatal maternal adversity to developmental outcomes in infants: the role of epigenetic pathways. Development and Psychopathology, v. 24, n. 4, p. 1361-1371, 2012. Disponível em: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3730125/. Acesso em: 15 mai. 2015.

NESTLER, E. J.; MALENKA, R. C. The addicted brain. Scientific American, New York, v. 290, n. 3, p. 78-85, 2004.

OLIVEIRA, M. P. M. T. Dependências: o homem a procura de si mesmo. São Paulo: Ícone, 2005.

OLIVEIRA, M. P. M. T. Internet e o risco da desmedida. Junguiana, São Paulo, v. 32, n. 1, p. 30-38, 2013.

PALMINI, A. A tomada de decisão e as patologias da vontade: o cérebro em constante conflito. In: GIGLIOTTI, A.; GUIMARÃES, A. Dependência, compulsão e impulsividade. Rio de Janeiro: Rubio, 2007. p. 1-7.

PROVENÇAL, N.; SUDERMAN, M. J.; GUILLEMIN, C. et al. The signature of maternal rearing in the methylome in rhesus macaque prefrontal cortex and T cells. The Journal of Neuroscience, v. 32, n. 44, p. 15626-15642, 2012. Disponível em: https://www.ncbi.nlm.nih.gov/pubmed/23115197. Acesso em: 17 mai. 2015.

RIZZOLATTI, G.; ARBIB, M. A. Language within our grasp. Trends in neurosciences, Cambrige, MA, v. 21, n. 5, p.188-194, 1998.

SAÑUDO, A.; ANDREONI, S.; SANCHEZ, Z. M. Polydrug use among nightclub patrons in a megacity: a latent class analysis. International Journal of Drug Policy, 2015. Disponível em: http://www.baladacomciencia.com.br/images/arquivos/Sanudo%20et%20al%202015%20IJDP.pdf. Acesso em: 2 nov. 2015.

STERN, D. N. The interpersonal world of the infant. Nova York: Basic Books, 2000.

STERN, D. N. O momento presente na psicoterapia e na vida cotidiana. Rio de Janeiro: Record, 2004.

TREMBLAY, R. E. Developmental origins of disruptive behavior problems: the ‘original sin’ hypothesis, epigenetics and their consequences for prevention. Journal of Child Psychology and Psychiatry, London, v. 51, n. 4, p. 341-367, 2010.

VERDEJO-GARCÍA, A.; BECHARA, A. A somatic-marker theory of addiction. Neuropharmacology, v. 56, n. 1, p. 48-62, 2009. Disponível em: http://www.fafich.ufmg.br/cogvila/criancaadolescente/bechara_2008.pdf. Acesso em: 23 mai. 2015.

YAN, W.-S.; LI, Y.-H.; XIAO, L.; ZHU, N.; BECHARA, A.; SUI, N. Working memory and affective decision-making in addiction: a neurocognitive comparison between heroin addicts, pathological gamblers and healthy controls. Drug and Alcohol Dependence, v. 134, p. 194-200, 2013. Disponível em: https://www.ncbi.nlm.nih.gov/pubmed/24268669. Acesso em: 23 mai. 2015.

Published

2017-02-12

How to Cite

Oliveira, M. P. M. T. de. (2017). Prevention starts at home: contributions from neuroscience. JUNGUIANA , 35(1), 21–31. Retrieved from https://junguiana.sbpa.org.br/revista/article/view/268

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Section

Articles